Download the Application note: In vivo imaging of renal fibrosis using col-F

In this application note, two markers for imaging renal fibrosis in vivo are evaluated: fluorescein and col-F. The cellular-resolution images obtained with Cellvizio Dual Band gave information about the extent and the localization of collagen and elastin aggregates within the fibrotic kidney.

This application note describes:

  • The unilateral ureteral obstruction (UUO) model to induce kidney fibrosis in mouse
  • The use of Cellvizio Lab to image kidney fibrosis in vivo in a minimally invasive manner
  • The correlation of Cellvizio imaging with ex vivo whole-body imaging and conventional histology